Research preview · Study design in progress
Evaluating a cross-platform kidney atlas as a reusable reference.
Scilytica is studying whether a cross-platform kidney atlas can serve as a stable reference for new CosMx and Xenium patient samples.
This question has practical implications for how patient samples can be analyzed, compared, and reported in a translational research setting.
Clinical samples may arrive gradually over months or years, while research must continue before the full cohort is available. Rebuilding the atlas or changing how each new sample is processed, mapped, reviewed, and reported can turn the analysis into a moving target. Differences between patients may then reflect changes in the analytical process as well as changes in the underlying biology.
A stable reference is therefore only one part of the solution. The surrounding analytical system must also preserve the methods, parameters, software, quality controls, provenance, and review process used for each sample. Together, a stable reference and a reproducible analytical system would allow new samples to be evaluated as they arrive while maintaining consistent comparisons with earlier patients.
Study design and validation are in progress. Results will be shared after review.